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A Liver Function Test Helps With Liver Surgeries

Liver function tests are performed on blood samples and measure the values of enzymes and other substances produced by the liver. These substances include:

  • Alanine transaminase (ALT)
  • Albumin
  • Alkaline phosphatase
  • Alpha-fetoprotein
  • Aspartate transaminase (AST)
  • Bilirubin
  • Gamma-glutamyltranspeptidase
  • Lactate dehydrogenase
  • 5'-nucleotidase

The values of these substances measure the effectiveness of normal liver protein production and bile secretion. The values of other substances detect the presence and degree of liver inflammation. However, sometimes the values can be much higher than the norm, generally because the subject is suffering from other disorders.

One of the liver function tests is prothrombin time (prothrombin time, PT), used to calculate the international normalized ratio (international normalized ratio, INR). An abnormal result on the PT or INR test may indicate the presence of acute liver disease. In chronic liver diseases, an increasing PT or INR value usually indicates progression to liver failure.

Reliability of liver function tests

Both liver function tests are very reliable. While the blood test initially provides an overview of a possible disease of the organ, the Liver Function Test cost in Delhi provides reliable data on the functioning of the organ and can thus save lives. Because if the surgical risk is known, the surgery can be done with appropriate precautions. But even with the latest methods, surgery on the liver is always a risky procedure.

How does this liver function test work?

At the beginning of the test, patients receive an injection of methacetin.

Methacetin is an enzyme that is harmless to the human body and rapidly converts to CO2 (carbon dioxide) and paracetamol. This transformation makes a detoxification enzyme that is formed in the liver. The decomposition product CO2 is released to the outside through the breathing air. To analyze the respiratory air and its carbon dioxide content and thereby determine how fast the enzyme works, the patients are given a specially designed respiratory mask for this purpose. Thus, the enzyme performance of the liver can be measured, and an assessment of the surgical risk can be made.

The less carbon dioxide in the exhaled air, the worse the liver works. In this case, preliminary damage to the liver is assumed, and the surgical risk is very high.

What do you do if your liver function is insufficient for surgery?

We cannot improve the function itself, but the volume, by stimulating liver growth before surgery. For example, a vessel is closed so that the diseased part of the liver, which has to be removed anyway, shrinks. The cells of the healthy liver area notice that they have to do more and make this part grow. In some cases, this helps very well and allows partial surgery.

Another variation is to change the therapy methods. For example, you can "burn" individual offshoots with a special procedure or prefer a drug therapy.

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7/8/2019 7:59 AM
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The World Health Organization (WHO) is a specialized agency of the United Nations that is concerned with international public health
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